Cuevas JM, Moya A & Sanjuán 2009 A genetic background with low mutational robustness is associated with increased adaptability to a novel host in an RNA virus. J Evol Biol 22:2041-2048. robustness can promote evolvability only in systems w…

Sanjuán R & Nebot MR 2008 A network model for the correlation between epistasis and genomic complexity. PLoS ONE 3:e2663. in simpler genomes epistasis is antagonistic on average a transition towards synergistic epistasis occurs in more com…

Keightley PD & Eyre-Walker A 1999 Terumi Mukai and the riddle of deleterious mutation rates. Genetics 153:515-523. one approach to estimating the mutation rate to deleterious, but nonlethal, mutations is to use information on the rate at w…

Keightley PD, Caballero A & García-Dorado A 1998 Population genetics: surviving under mutation pressure. Curr Biol 8:R235-R237. it is extremely difficult to obtain information on the impact of mildly deleterious mutations currently, much o…

Eyre-Walker A & Keightley PD 2007 The distribution of fitness effects of new mutations. Nat Rev Genet 8:610-618. there is also some evidence that the DFE of homozygous non-lethal mutations is multi-modal

Bataillon T 2000 Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations? Heredity 84:497-501.

Phadnis N & Fry JD 2005 Widespread correlations between dominance and homozygous effects of mutations: implications for theories of dominance. Genetics 171:385-392. empirical studies of mutations affecting viability in Drosophila (reviewed…

Fry JD 2001 Rapid mutational declines of viability in Drosophila. Genet Res 77:53-60. Mukai and Ohnishi may have confounded viability declines caused by mutation with declines resulting from environmental changes or other extraneous factor…

Fry JD, Keightley PD, Heinsohn SL & Nuzhdin SV 1999 New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster. PNAS 96:574-579. the most detailed information comes from the work of Mukai and Ohnishi w…

García-Dorado A, López-Fanjul C & Caballero A 1999 Properties of spontaneous mutations affecting quantitative traits. Genet Res 74:341-350. although the rate (λ) and effect (s) of very slight deleterious mutation remain unknown, most mutat…

García-Dorado A & Caballero A 2000 On the average coefficient of dominance of deleterious spontaneous mutations. Genetics 155:1991-2001. the results of these experiments, although inconsistent, have been interpreted as indicating slight re…

Rodríguez-Ramilo ST, Pérez-Figueroa A, Fernández B, Fernández J & Caballero A 2004 Mutation-selection balance accounting for genetic variation for viability in Drosophila melanogaster as deduced from an inbreeding and artificial selection …

García-Dorado A, López-Fanjul C & Caballero A 2004 Rates and effects of deleterious mutations and their evolutionary consequences. Pages 20-32 in Moya A & Font E, eds. Evolution: from molecules to ecosystems. Oxford UP. ISBN:9780198515432

Caballero A, Cusi E, García C & García-Dorado A 2002 Accumulation of deleterious mutations: additional Drosophila melanogaster estimates and a simulation of the effects of selection. Evolution 56:1150-1159. the simulation results indicated…

Caballero A & Keightley PD 1994 A pleiotropic nonadditive model of variation in quantitative traits. Genetics 138:883-890. as mutant effects increase, there is a tendency toward recessivity we assumed an exponential function to define limi…

Theodorou K, Souan H & Couvet D 2009 Metapopulation persistence in fragmented landscapes: significant interactions between genetic and demographic processes. J Evol Biol 22:152-162. the dominance coefficient of mutations were obtained from…

Theodorou K & Couvet D 2006 Genetic load in subdivided populations: interactions between the migration rate, the size and the number of subpopulations. Heredity 96:69-78. in order to investigate the relative importance of the parameters th…

Thévenon S & Couvet D 2002 The impact of inbreeding depression on population survival depending on demographic parameters. Anim Conserv 5:53-60. a mix of 95% of mildly deleterious alleles and 5% of strongly detrimental alleles was consider…

Lande R 1988 Genetics and demography in biological conservation. Science 241:1455-1460. roughly half the inbreeding depression is due to individually rare, but collectively abundant, nearly recessive lethal and semi-lethal mutations at abo…

Glémin S 2007 Mating systems and the efficacy of selection at the molecular level. Genetics 177:905-916. variation in dominance levels is less documented both theoretical (Bourguet 1999) and experimental arguments (Phadnis and Fry 2005) su…

Higgins K & Lynch M 2001 Metapopulation extinction caused by mutation accumulation. PNAS 98:2928-2933. we let h(s) = 1 / (2 + 20s) mutations of large effect are almost recessive (as s → 1, h → 0.045), whereas those of small effect are almo…

Woodworth LM, Montgomery ME, Briscoe DA & Frankham R 2002 Rapid genetic deterioration in captive populations: causes and conservation implications. Conserv Genet 3:277-288. inbreeding depression and genetic adaptation were responsible for …

Gilligan DM, Woodworth LM, Montgomery ME, Briscoe DA & Frankham R 1997 Is mutation accumulation a threat to the survival of endangered populations? Conserv Biol 11:1235-1241. no trend of smaller populations exhibiting greater genetic loads…

Lande R 1995 Mutation and conservation. Conserv Biol 9:782-791. because they arise at much higher spontaneous rates than do recessive lethal mutation, mildly detrimental mutations on the border of neutrality are the most damaging to popula…

Wittkopp PJ 2007 Variable gene expression in eukaryotes: a network perspective. J Exp Biol 210:1567-1575. meta-analysis of comparative genomic expression data concludes that regulatory evolution is characterized by strong stabilizing selec…

Deutscher D, Meilijson I, Schuster S & Ruppin E 2008 Can single knockouts accurately single out gene functions? BMC Systems Biol 2:50. in non-trivial biological systems single-perturbations will fail to reveal the functional organization o…

Wayne ML, Telonis-Scott M, Bono LM, Harshman L, Kopp A, Nuzhdin SV & McIntyre LM 2007 Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster. PNAS 104:18577-18582. hemizygosity of the X could cause fundame…