deleterious mutation & demography

Thévenon S & Couvet D 2002 The impact of inbreeding depression on population survival depending on demographic parameters. Anim Conserv 5:53-60.

  • a mix of 95% of mildly deleterious alleles and 5% of strongly detrimental alleles was considered
  • these alleles are supposed to involve different loci
  • we considered 47,500 loci with s = 0.01, h = 0.25 and 2500 loci with s = 0.99, h = 0.02
  • the mutation rate per allele and per generation is μ = 10−5
  • the genomic mutation rate is 0.95 for the mildly deleterious alleles and 0.05 for the quasi-lethal ones