Entries from 2009-03-01 to 1 month

heritability

Ayroles JF, Carbone MA, Stone EA, Jordan KW, Lyman RF, Magwire MM, Rollmann SM, Duncan LH, Lawrence F, Anholt RR & Mackay TF 2009 Systems genetics of complex traits in Drosophila melanogaster. Nat Genet 41:299-307. we observed 10,096 genet…

population expansion

Charlesworth J & Eyre-Walker A 2007 The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations. PNAS 104:16992-16997. when there are both slightly deleterious and advantageous back-mutations, there is lik…

QLE

Kirkpatrick M, Johnson T & Barton N 2002 General models of multilocus evolution. Genetics 161:1727-1750. Dij = eij pqij / rij + O(a2) ... (A5) [Watterson?] we derive approximate expressions for the associations and changes in allele freque…

quantitative trait mapping

Weir BS 2008 Linkage disequilibrium and association mapping. Annu Rev Genom Hum Genet 9:129-142. dichotomous traits: case only Pr(MM|Case) = pM2 + (1 / μG) [pMρMTσAT√(2pMpm) + ρMT2σDTpMpm] Pr(Mm|Case) = 2pMpm + (1 / μG) [(pm − pM)ρMTσAT√(2…