Szép E, Sachdeva H & Barton NH 2021 Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model. Evolution, in press. doi:10.1111/evo.14210 we assume hard selection population sizes are stochastic but influenced by m…

Stephan W & John S 2020 Polygenic adaptation in a population of finite size. Entropy 22:907. in recent years, due to the advance of genome-wide association studies (GWAS), polygenic selection was studied using quantitative genetics models …

John S & Stephan W 2020 Important role of genetic drift in rapid polygenic adaptation. Ecol Evol 10:1278-1287. it is not clear if adaptation can occur rapidly via such subtle changes in the allele frequencies we follow this direction here …

Mathieson I 2020 Human adaptation over the past 40,000 years. Curr Opin Genet Dev 62:97-104. despite strong evidence of the polygenicity of most human traits, evidence for polygenic selection is weak its importance in recent human evolutio…

Wakeley J 2020 Developments in coalescent theory from single loci to chromosomes. Theor Popul Biol 133:56-64. it took some time to understand the temporal structure behind Ewens' formula working at first outside population genetics, Kingma…

Bürger R 2020 Multilocus population-genetic theory. Theor Popul Biol 133:40-48. commentary in linkage equilibrium (LE), allele frequencies at different loci do not change independently the direction and intensity of selection on a particul…

Osmond MM, Otto SP & Martin G 2020 Genetic paths to evolutionary rescue and the distribution of fitness effects along them. Genetics 214:493-510. in multi-step rescue, intermediate genotypes that themselves go extinct provide a "springboar…

Johri P, Charlesworth B & Jensen JD 2020 Toward an evolutionarily appropriate null model: jointly inferring demography and purifying selection. Genetics 215:173-192. previous studies have inferred ~two- to fourfold growth in the Zambian po…

Martin G & Lambert A 2015 A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations. Theor Popul Biol 101:40-46. the main tool to obtain the distribution of allelic frequencies at at given time…

Charlesworth B 2020 How long does it take to fix a favorable mutation, and why should we care? Am Nat 195:753-771. R. A. Fisher independently described a deterministic model of selection at an autosomal locus with discrete generations in a…

Waxman D & Overall ADJ 2020 Influence of dominance and drift on lethal mutations in human populations. Front Genet 11:267. a lethal disease-causing allele needs to be described by a modified Wright-Fisher model, which deviates from the sta…

Hartfield M & Bataillon T 2020 Selective sweeps under dominance and inbreeding. G3:1063-1075. a key property of soft sweeps is that the beneficial variant is present on multiple genetic backgrounds as it sweeps to fixation recessive allele…

Sella G & Barton NH 2019 Thinking about the evolution of complex traits in the era of genome-wide association studies. Annu Rev Genom Hum Genet 20:461-493. the genetic architecture of a trait is informative about the population genetic pro…

Hayward LK & Sella G 2019 Polygenic adaptation after a sudden change in environment. bioRχiv 792952. doi:10.1101/792952 hard sweeps were rare, at least over the past ~500,000 years of human evolution (13, 14) for many traits, estimates of …

Thornton KR 2019 Polygenic adaptation to an environmental shift: temporal dynamics of variation under Gaussian stabilizing selection and additive effects on a single trait. Genetics 213:1513-1530. detectable "hitchhiking" patterns are only…

Wray NR, Wijmenga C, Sullivan PF, Yang J & Visscher PM 2018 Common disease is more complex than implied by the core gene omnigenic model. Cell 173:1573-1580. Boyle et al. (2017b) [...] introduce the term "omnigenic," (omni = "all") in ackn…

Boyle EA, Li YI & Pritchard JK 2017 The omnigenic model: response from the authors. J Psychiat Brain Sci 2:S8. one of our goals in writing this paper was to highlight an apparent paradox in human genetics most of the heritability for a typ…

Liu X, Li YI & Pritchard JK 2019 Trans effects on gene expression can drive ominigenic inheritance. Cell 177:1022-1034. we provide a formal model in which genetic contributions to complex traits are partitioned into direct effects from cor…

Zheng Y & Wiehe T 2019 Adaptation in structured populations and fuzzy boundaries between hard and soft sweeps. PLoS Comput Biol 15:e1007426. train- and test-sets must have the same, or at least similar, demographic parameters so that demog…

Palacios JA, Véber A, Cappello L, wang Z, Wakeley J & Ramachandran S 2019 Bayesian estimation of population size changes by sampling Tajima's trees. Genetics 213:967-986. our objective in the implementation of BESTT is to estimate the post…

Palacios JA, Wakeley J & Ramachandran S 2015 Bayesian nonparametric inference of population size changes from sequential genealogies. Genetics 201:281-304. we address a key problem for inference of population size trajectories under sequen…

Lee KM & Coop G 2019 Population genomics perspectives on convergent adaptation. Phil Trans R Soc B 374:20180236. the sharing of traits or alleles incongruent with the population or species tree owing to ancestral variation (i.e. ILS shown …

Ragsdale AP & Gravel S 2019 Models of archaic admixture and recent history from two-locus statistics. PLoS Genet 15:e1008204. human expansion models underestimate LD between low frequency variants the demographic model for human out-of-Afr…

Hallgrimsson B, Green RM, Katz DC, Fish JL, Bernier FP, Roseman CC, Young NM, Cheverud JM & Marcucio RS 2019 The developmental-genetics of canalization. Sem Cell Dev Biol 88:67-79. canalization is a potentially significant cause of missing…

Thompson KA, Osmond MM & Schluter D 2019 Parallel genetic evolution and speciation from standing variation. Evol Lett 3:129-141. adaptation from standing variation would reduce the evolution of reproductive isolation under parallel selecti…

Höllinger I, Pennings PS & Hermisson J 2019 Polygenic adaptation: from sweeps to subtle frequency shifts. PLoS Genet 15:e1008035. population genetics views adaptation as a sequence of selective sweeps at single loci underlying the trait qu…

Stetter MG, Thornton K & Ross-Ibarra J 2018 Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima. PLoS Genet 14:e1007794. during the stationary phase before the shift and after reaching the new optim…

Barton N, Hermisson J & Nordborg M 2019 Why structure matters. eLife 8:e45380. the first GWAS for height found a small number of SNPs that jointly explained only a tiny fraction of the variation this was in contrast with the high heritabil…

Edge MD & Coop G 2019 Reconstructing the history of polygenic scores using coalescent trees. Genetics 211:235-262. standard population-genetic methods for inferring evolutionary history are lii-suited for polygenic traits when there are ma…

Nicholson G, Smith AV, Jónsson F, Gústafsson Ó, Stefánsson K & Donnelly P 2002 Assessing population differentiation and isolation from single-nucleotide polymorphism data. J R Stat Soc B 64:695-715. in the Balding-Nichols (BN) model, allel…