Entries from 2016-11-01 to 1 month

missing heritability

Shi H, Kichaev G & Pasaniuc B 2016 Contrasting the genetic architecture of 30 complex traits from summary association data. Am J Hum Genet 99:139-153. a fraction of the missing heritability is due to multiple causal variants or poor taggin…

epistasis

Sackton TB & Hartl DL 2016 Genotypic context and epistasis in individuals and populations. Cell 166:279-287. in human genetics, direct studies are rarely possible inferences about physiological epistasis instead rely on estimates of statis…

epistasis

Huang W & Mackay TFC 2016 The genetic architecture of quantitative traits cannot be inferred from variance component analysis. PLoS Genet 12:e1006421. ideally, a variance component partition should have a one-to-one corresponding relations…

epistasis

Paixão T & Barton N 2016 The effect of gene interactions on the long-term response to selection. PNAS 113:4422-4427. a population under selection can reach trait values far beyond the initial trait variance it displays the epistasis among …