Entries from 2011-06-01 to 1 month

directional epistasis

Chou H-H, Chiu H-C, Delaney NF, Segré D & Marx CJ 2011 Diminishing returns epistasis among beneficial mutations decelerates adaptation. Science 332:1190-1192. epistasis has substantial impacts on evolution, in particular, the rate of adapt…

directional epistasis

Khan AI, Dinh DM, Schneider D, Lenski RE & Cooper TF 2011 Negative epistasis between beneficial mutations in an evolving bacterial population. Science 332:1193-1196. negative epistasis contributes to declining rates of adaptation over time…

directional epistasis

Kryazhimskiy S, Draghi JA & Plotkin JB 2011 In evolution, the sum is less than its parts. Science 332:1160-1161.

directional epistasis

Agrawal AF & Whitlock MC 2010 Environmental duress and epistasis: how does stress affect the strength of selection on new mutations? TREE 25:450-458. when Sanjuan and Elena plotted the average epistasis of each species against the species …

epistasis

Kvitek DJ & Sherlock G 2011 Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape. PLoS Genet 7:e1002056. adaptive mutations in two genes appear several times in different …

epistasis

Moore JH 2009 From genotypes to genometypes: putting the genome back in genome-wide association studies. Eur J Hum Genet 17:1205-1206. there are not enough computers in the world to exhaustively enumerate all the three-way, four-way and fi…

epistasis

Moore JH & Williams SM 2005 Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. BioEssays 27:637-646. one can argue that genetic and biological variation is sufficient…

epistasis

Moore JH 2005 A global review of epistasis. Nat Genet 37:13-14. biology and genetics are undergoing a "new modern synthesis"7 with the merger of population genetics and biotechnology into what has been called 'systems biology'

epistasis

Moore JH & Williams SM 2009 Epistasis and its implications for personal genetics. Am J Hum Genet 85:309-320. genetic epidemiology has preferred Fisher's definition of epistasis to Bateson's this has led to analytical approaches that signif…

parallel evolution

Tennessen JA & Akey JM 2011 Parallel adaptive divergence among geographically diverse human populations. PLoS Genet 7:e1002127. most putative examples of adaptive divergence between human populations lack the full signature of a classic ha…