Entries from 2016-03-01 to 1 month

mutation

Lynch M 2016 Mutation and human exceptionalism: our future genetic load. Genetics 202:869-875. the human germline mutation rate is higher than that in any other well-studied species human somatic mutation rates are substantially elevated a…

resistance evolution

Feder AF, Thee S-Y, Holmes SP, Shafer RW, Petrov DA & Pennings PS 2016 More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1. eLife 5:e10670. we use 6717 HIV-1 consensus sequences from patients t…