Beltrao P, Cagney G & Krogan NJ 2010 Quantitative genetic interactions reveal biological modularity. Cell 141:739-745. new technologies have increased the size and scope of biological data systems approaches have broadened the view of how …

Stelkens RB, Schmid C, Selz O & Seehausen O 2009 Phenotypic novelty in experimental hybrids is predicted by the genetic distance between species of cichlid fish. BMC Evol Biol 9:283. transgression is most commonly due to complementary gene…

Zhao K, Wright M, Kimball J, Eizenga G, McClung A, Kovach M, Tyagi W, Ali ML, Tung C-W, Reynolds A, Bustamante CD & McCouch SR 2010 Genomic diversity and introgression in O. sativa reveal the impact of domestication and breeding on the ric…

Zhong Q, Simonis N, Li Q-R, Charloteaux B, Heuze F, Klitgord N, Tam S, Yu H, Venkatesan K, Mou D, Swearingen V, Yildirim MA, Yan H, Dricot A, Szeto D, Lin C, Hao T, Fan C, Milstein S, Dupuy D, Brasseur R, Hill DE, Cusick ME & Vidal M 2009 …

Walhout AJM 2009 Getting an edge on human disease. Mol Systems Biol 5:322. networks are composed of proteins (nodes) and the physical interactions between them (edges) mutated residues are more likely to be buried in the protein when all i…

Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, Courtland H-W, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES & Nadeau JH 2008 Genetic architecture of complex traits: large phenotypic effects and pervasive ep…

Crow JF 2008 Maintaining evolvability. J Genet 87:349-353. long-term selection experiments show that populations continue to retain seemingly undiminished additive variance despite large changes in the mean value there are several reasons …

Crow JF 2010 On epistasis: why it is unimportant in polygenic directional selection. Phil Trans R Soc Lond B 365:1241-1244. epistatic variance has minimum effect, since the selected population soon arrives at a state in which the rate of c…

Orr HA 2010 The population genetics of beneficial mutations. Phil Trans R Soc Lond B 365:1195-1201. population genetics arose from the fusion of Darwin's theory of adaptation by natural selection with Mendel's theory of inheritance the fie…

Bell G 2009 The oligogenic view of adaptation. Cold Spring Harb Symp Quant Biol 74:139-44. hundreds of loci of small effect may contribute to variation in character state adaptation is predominantly caused by alleles of large effect in man…

Eyre-Walker A 2010 Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. PNAS 107:1752-1756. each rare mutation tends to contribute more to the variance than each common mutation thes…