edgetics

Zhong Q, Simonis N, Li Q-R, Charloteaux B, Heuze F, Klitgord N, Tam S, Yu H, Venkatesan K, Mou D, Swearingen V, Yildirim MA, Yan H, Dricot A, Szeto D, Lin C, Hao T, Fan C, Milstein S, Dupuy D, Brasseur R, Hill DE, Cusick ME & Vidal M 2009 Edgetic perturbation models of human inherited disorders. Mol Systems Biol 5:321.

• distinct mutations causing distinct molecular defects to proteins may lead to distinct perturbations of cellular network
• truncations close to the start of an open-reading frame, or mutations that grossly destabilize a protein structure, can be modeled as removing a protein node from the network ('node removal')
• single amino-acid substitutions that affect specific binding sites, or truncations that preserve certain domains of a protein, may give rise to partially functional gene products with specific changes in distinct biophysical or biochemical interaction(s)
• edge-specific genetic perturbation or 'edgetic' perturbations