Barton NH 2010 Genetic linkage and natural selection. Phil Trans R Soc Lond B 365:2559-2569. can we really believe that natural populations are subject to the homogeneous selection envisaged by the current view of molecular evolution? almo…

Hall MC, Lowry DB & Willis JH 2010 Is local adaptation in Mimulus guttatus caused by trade-offs at individual loci? Mol Ecol 19:2739-2753. local adaptation is largely controlled by non-overlapping loci reduced gene flow prevents the evolut…

Kaessmann H 2010 Origins, evolution, and phenotypic impact of new genes. Genome Res 20:1313-1326. the observation of numerous functional retrogenes in various genomes (detailed below) immediately raises the question of how retrocopies can …

Kaessmann H, Vinckenbosch N & Long M 2009 RNA-based gene duplication: mechanistic and evolutionary insights. Nat Rev Genet 10:19-31. intron gains are rare events during evolution intron loss seems to be more frequent in mammals, for exampl…

Okamura K & Nakai K 2008 Retrotransposition as a source of new promoters. Mol Biol Evol 25:1231-1238. we identified 29 gene pairs in the human genome, consisting of a functional retrotransposed gene and its parental gene a large part of th…

Coop G, Witonsky D, Di Rienzo A & Pritchard JK 2010 Using environmental correlations to identify loci underlying local adaptation. Genetics 185:1411-1423. loci involved in local adaptation can potentially be identified by an unusual correl…

Ralph P & Coop G 2010 Parallel adaptation: one or many waves of advance of an advantageous allele? Genetics 186:647-668. we study various models of parallel mutation in a continuous, geographically spread population adapting to a global se…

Hancock AM, Witonsky DB, Ehlera E, Alkorta-Aranburu G, Beallc C, Gebremedhind A, Sukernike R, Utermannf G, Pritchard JK, Coop G & Di Rienzo A 2010 Human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele fre…

Hancock AM, Witonsky DB, Gordon AS, Eshel G, Pritchard JK, Coop G & Di Rienzo A 2008 Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet 4:e32.

Hancock AM, Alkorta-Aranburu G, Witonsky DB & Di Rienzo A 2010 Adaptations to new environments in humans: the role of subtle allele frequency shifts. Phil Trans R Soc Lond B 365:2459-2468. we contrast the results of approaches based on hap…

Pritchard JK & Di Rienzo A 2010 Adaptation — not by sweeps alone. Nat Rev Genet 11:665-667. within the population genetics community, adaptation is typically viewed as involving selective sweeps that drive beneficial alleles from low to hi…

Lynch M & Abegg A 2010 The rate of establishment of complex adaptations. Mol Biol Evol 27:1404-1414. a central problem in evolutionary theory concerns the mechanisms by which adaptations requiring multiple mutations emerge in natural popul…

Lynch M 2010 Scaling expectations for the time to establishment of complex adaptations. PNAS 107:16577-16582. one strategy has been to ignore all deleterious mutations and to assume that selection is strong enough and mutation weak enough …

Weissman DB, Feldman MW & Fisher DS 2010 The rate of fitness-valley crossing in sexual populations. Genetics, in press. doi:10.1534/genetics.110.123240 ISSUE HIGHLIGHTS how do populations acquire complex adaptations that require multiple m…

Weissman DB, Desai MM, Fisher DS & Feldman MW 2009 The rate at which asexual populations cross fitness valleys. Theor Popul Biol 75:286-300. once a beneficial mutation is established (upon reaching a size of order 1 / s), its frequency wil…

Neher RA, Shraiman BI & Fisher DS 2010 Rate of adaptation in large sexual populations. Genetics 184:467-481. adaptation often involves the acquisition of a large number of genomic changes that arise as mutations in single individuals in as…

Iwasa Y, Minchor F & Nowak MA 2004 Stochastic tunnels in evolutionary dynamics. Genetics 166:1571-1579. cells reproduce asynchronously we use a Moran process instead of the standard Wright-Fisher model each elementary step of the stochasti…

Wang Y, Diehl A, Wu F, Vrebalov J, Giovannoni J, Siepel A & Tanksley SD 2008 Sequencing and comparative analysis of a conserved syntenic segment in the Solanaceae. Genetics 180:391-408. despite their great phenotypic diversity, all Solanac…