Entries from 2017-08-01 to 1 month

soft sweep

Hermisson J & Pennings PS 2017 Soft sweeps and beyond: understanding the patterns and probabilities of selection footprints under rapid adaptation. Methods Ecol Evol 8:700-716. complex footprints observed in data are, as yet, insufficientl…

conditional process

Kern AD & Schrider DR 2016 Discoal: flexible coalescent simulations with selection. Bioinf 32:3839-3841. conditioning on selected allele trajectories is performed in discoal one of two possible ways sweeps can follow deterministic trajecto…

soft sweep

McCoy RC & Akey JM 2017 Selection plays the hand it was dealt: evidence that human adaptation commonly targets standing genetic variation. Genome Biol 18:139. Schrider and Kern [1] ... argue that adaptation is pervasive, but commonly targe…

soft sweep

Schrider DR & Kern AD 2017 Soft sweeps are the dominant mode of adaptation in the human genome. Mol Biol Evol 34:1863–1877. soft sweeps are widespread and account for the vast majority of recent human adaptation the search for selective sw…

polygenic adaptation

Bod'ová K, Tkacik G & Barton NH 2016 A general approximation for the dynamics of quantitative traits. Genetics 202:1523-1548. we cannot hope to predict the evolution of quantitative traits by using a direct population genetics approach bas…

epistasis

Barton N 2017 How does epistasis influence the response to selection? Heredity 118:96–109. stabilising selection can maintain many traits close to their optima, even when the underlying alleles are weakly selected the number of traits that…

evolutionary rescue

Wilson BA, Pennings PS & Petrov DA 2017 Soft selective sweeps in evolutionary rescue. Genetics 205:1573-1586. (Wilson et al. 2014) we had assumed that demography was independent of the allelic state at the locus under selection an assumpti…