Entries from 2014-01-01 to 1 year

conditional process

Zhao L, Lascoux M & Waxman D 2014 Exact simulation of conditioned Wright-Fisher models. J Theor Biol 363:419-426. less attention was initially paid to soft sweeps – where selection acts on standing variation rather than on new mutations th…

fixation probability

McCandlish DM, Epstein CL & Plotkin JB 2015 Formal properties of the probability of fixation: identities, inequalities and approximations. Theor Popul Biol, in press. doi:10.1016/j.tpb.2014.11.004 we consider the classical problem of deter…

markovian

Tenaillon O 2014 The utility of Fisher's geometric model in evolutionary genetics. Annu Rev Ecol Evol Syst 45:179-201. beneficial mutations have very small effects there would be no experimental power to analyze them the individual propert…

epistasis

Hemani G, Shakhbazov K, Westra H-J, Esko T, Henders AK, McRae AF, Yang J, Gibson G, Martin NG, Metspalu A, Franke L, Montgomery GW, Visscher PM & Powell JE 2014 Hemani et al. reply. Nature 514:E5-E6. replying to A. R. Wood et al. weaker in…

epistasis

Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM & Weedon MN 2014 Another explanation for apparent epistasis. Nature 514:E3-E5. arising from G. Hemani et al. the apparent epistasis rep…

soft sweep

Vitti JJ, Grossman SR & Sabeti PC 2013 Detecting natural selection in genomic data. Nat Rev Genet 47:97-120. LD-based approaches are particularly useful for identifying variants that have undergone a partial or incomplete selective sweep t…

soft sweep

Jensen JD 2014 On the unfounded enthusiasm for soft selective sweeps. Nat Commun 5:5281. the rate of adaptation is not strongly limited by the rate at which newly arising beneficial mutations enter the population empirical and experimental…

Gattuso

http://www.tuttosport.com/calcio/calcio_estero/2014/10/20-309928/

polygenic adaptation

Wollstein A & Stephan W 2014 Adaptive fixation in two-locus models of stabilizing selection and genetic drift. Genetics 198:685-697. selection on an adaptive character involves simultaneous selection at multiple loci controlling the trait …

population bottleneck

Wilson BA, Petrov DA & Messer PW 2014 Soft selective sweeps in complex demographic scenarios. Genetics 198:669-684. population bottlenecks can lead to the removal of all but one adaptive lineage from an initially soft selective sweep "hard…

soft sweep

Fagny M, Patin E, Enard D, Barreiro LB, Quintana-Murci L & Laval G 2014 Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets. Mol Biol Evol 31:1850-1868. we found that background selection …

soft sweep

Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Ragimbeau J, Pellegrini S, Abel L, Casanova JL & Quintana-Murci L 2009 Evolutionary dynamics of human…

forward-in-time simulation

Thornton KR 2014 A C++ template library for efficient forward-time population genetic simulation of large populations. Genetics 198:157-166. the individual-based method results in the fastest runtime for models involving natural selection …

ergodicity

Watterson GA 1975 On the number of segregating sites in genetical models without recombination. Theor Popul Biol 7:256-276. by a somewhat heuristic argument, implicitly applying an ergodic theorem to interpret the results for one site to m…

soft sweep

Roesti M, Gavrilets S, Hendry AP, Salzburger W & Berner D 2014 The genomic signature of parallel adaptation from shared genetic variation. Mol Ecol 23:3944-3956. implications for ecological genomics the common interpretation of regions exh…

markovian

McCandlish DM & Stoltzfus A 2014 Modeling evolution using the probability of fixation: history and implications. Q Rev Biol 89:225-252. early origin-fixation models were used to calculate an instantaneous rate of evolution across a large n…

polygenic adaptation

de Vladar HP & Barton N 2014 Stability and response of polygenic traits to stabilizing selection and mutation. Genetics 197:749-767. understanding quantitative genetics in terms of population genetics is crucial for both scientific and pra…

polygenic adaptation

Ferrer-Admetlla A, Liang M, Korneliussen T & Nielsen R 2014 On detecting incomplete soft or hard selective sweeps using haplotype structure. Mol Biol Evol 31:1275-1291. multiple independent mutations at a single locus are all favored and i…

recombination & selection

O'Reilly PF, Birney E & Balding DJ 2008 Confounding between recombination and selection, and the Ped/Pop method for detecting selection. Genome Res 18:1304-1313. we propose a novel genome-wide method for detecting selection("Ped/Pop") that…

evolutionary rescue

Orr HA & Unckless RL 2014 The population genetics of evolutionary rescue. PLoS Genet 10:e1004551. evolutionary rescue from new mutation takes longer and involves a smaller minimum population size than rescue from the standing genetic varia…

evolutionary rescue

Orr HA & Unckless RL 2008 Population extinction and the genetics of adaptation. Am Nat 172:160-169. some environmental challenges—challenges to which populations must adapt—may depress absolute fitness below 1, causing populations to decli…

absolute fitness

Gomulkiewicz R & Houle D 2009 Demographic and genetic constraints on evolution. Am Nat 174:E218-E229. the novel aspect of our approach is that it explicitly considers the joint dynamics of evolution and population size, revealing the direc…

evolutionary rescue

Gomulkiewicz R & Holt RD 1995 When does evolution by natural selection prevent extinction? Evolution 49:201-207. many examples are known in which populations have evolved sufficiently to persist in changed environments, such as cases of ev…

population expansion

Lohmueller KE 2014 The impact of population demography and selection on the genetic architecture of complex traits. PLoS Genet 10:e1004379. recent population growth increases the input of deleterious mutations into the population, directly…

population expansion

Simons YB, Turchin MC, Pritchard JK & Sella G 2014 The deleterious mutation load is insensitive to recent population history. Nat Genet 46:220-224. with growth, the increased number of segregating sites is balanced exactly by a decrease in…

twin studies

Evans DM, Gillespie NA & Martin NG 2002 Biometrical genetics. Biol Psychol 61:33-51. twin studies dominant genetic and common environmental components of variance cannot be estimated simultaneously these components are negatively confounde…

epistasis

Moore JH, Asselbergs FW & Williams SM 2010 Bioinformatics challenges for genome-wide association studies. Bioinformatics 26:445-455. most SNPs discovered via GWAS have small effects on disease susceptibility and thus may not be suitable fo…