markovian

Tenaillon O 2014 The utility of Fisher's geometric model in evolutionary genetics. Annu Rev Ecol Evol Syst 45:179-201.

• beneficial mutations have very small effects
• there would be no experimental power to analyze them
• the individual properties of mutations have rarely been the main focus of quantitative genetics
• few studies have tried to connect quantitative genetics with the adaptive fate of a single mutation (but see Chevin & Hospital 2008)
• per our current understanding of FGM and in line with Fisher's early work, de novo mutations are the center of attention
• most FGM studies use asexual populations with a low mutation rate such that the populations are monomorphic and can be described by a single point in the adaptive landscape (the classic strong-selection weak-mutation hypothesis)