Entries from 2012-06-01 to 1 month
Draghi JA & Plotkin JB 2011 Molecular evolution: hidden diversity sparks adaptation. Nature 474:45-46. Sewall Wright, a vigorous proponent of the importance of epistasis in evolution, presaged the modern view in his comment11 on Kimura's n…
Leinonen PH, Remington DL, Leppälä J & Savolainen O 2012 Genetic basis of local adaptation and flowering time variation in Arabidopsis lyrata. Mol Ecol, in press. doi:10.1111/j.1365-294X.2012.05678.x an allele yielding higher fitness in on…
Fournier-Level A, Korte A, Cooper MD, Nordborg M, Schmitt J & Wilczek AM 2011 A map of local adaptation in Arabidopsis thaliana. Science 334:86-89. among the 797 top SNPs, only 12 SNPs were associated with fitness in more than one environm…
Pavlidis P, Metzler D & Stephan W 2012 Selective sweeps in multilocus models of quantitative traits. Genetics, in press. doi:10.1534/genetics.112.142547 we study the trajectory of an allele that affects a polygenic trait selected towards a…
Coop G & Ralph PL 2012 Patterns of neutral diversity under general models of selective sweeps. Genetics, in press. doi:10.1534/genetics.112.141861 we develop a general model of recurrent selective sweeps in a coalescent framework, one that…
Weissman DB & Barton NH 2012 Limits to teh rate of adaptive substitution in sexual populations. PLoS Genet 8:e1002740. when multiple beneficial mutations arise simultaneously, they will typically occur in different individuals and will com…
Knief U, Schielzeth H, Kempenaers B, Ellegren H & Forstmeier W 2012 QTL and quantitative genetic analysis of beak morphology reveals patterns of standing genetic variation in an Estrildid finch. Mol Ecol, in press. doi:10.1111/j.1365-294X.…
Nelson MR, Wegmann D, Ehm MG, Kessner D, St Jean P, Verzilli C, Shen J, Tang Z, Bacanu S-A, Fraser D, Warren L, Aponte J, Zawistowski M, Liu X, Zhang H, Zhang Y, Li J, Li Y, Li L, Woollard P, Topp S, Hall MD, Nangle K, Wang J, Abecasis G, …
Gossmann TI, Keightley PD & Eyre-Walker A 2012 The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes. Genome Biol Evol 4:658-667. adaptation is to some extent limited by the supp…
Gravel S, Henn BM, Gutenkunst RN, Indap AR, Marth GT, Clark AG, Yu F, Gibbs RA, 1000 Genomes Project & Bustamante CD 2011 Demographic history and rare allele sharing among human populations. PNAS 108:11983-11988. the one-population site fr…
van Herwaarden OA & van der Wal N 2002 Extinction time and age of an allele in a large finite population. Theor Popul Biol 61:311-318. c = (ln(8Nes) + (2 − 3h) ln(h) + (3h − 1) ln(1 − h) + γ) / (2sh(1 − h)) ... (19) for initial frequencies…
Waxman D 2011 A compact result for the time-dependent probability of fixation at a neutral locus. J Theor Biol 274:131-135. an important feature of the form of Pfix(τ;p) given in Eq. (3) is that the smaller the value of τ, the smaller the …
Waxman D 2012 Population growth enhances the mean fixation time of neutral mutations and the persistence of neutral variation. Genetics 191:561-577. for populations that increase in size, the mean time of fixation can be enhanced, sometime…
Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, Abecasis G, Altshuler D, Nickerson DA, Boerwinkle E, Sunyaev S, Bustamante CD, Bamshad MJ, Akey …
Keinan A & Clark AG 2012 Recent explosive human population growth has resulted in an excess of rare genetic variants. Science 336:740-743. for European history, these studies estimated as much as 0.5% growth in effective population size pe…
Coventry A, Bull-Otterson LM, Liu X, Clark AG, Maxwell TJ, Crosby J Hixson JE, Rea TJ, Muzny DM, Lewis LR, Wheeler DA, Sabo A, Lusk C, Weiss KG, Akbar H, Cree A, Hawes AC, Newsham I, Varghese RT, Villasana D, Gross S, Joshi V, Santibanez J…
Wegmann D, Currat M & Excoffier L 2006 Molecular diversity after a range expansion in heterogeneous environments. Genetics 174:2009-2020. the pattern of molecular diversity observed after a range expansion is different from that expected a…
Kimura M & Ohta T 1974 Probability of gene fixation in an expanding finite population. PNAS 71:3377-3379. we have obtained (6), based on diffusion models (see ref. 7), the probability of fixation of a mutant gene in a finite population whe…
Huang C-C, Hung K-H, Wang W-K, Ho C-W, Huang C-L, Hsu T-W, Osada N, Hwang C-C & Chiang T-Y 2012 Evolutionary rates of commonly used nuclear and organelle markers of Arabidopsis relatives (Brassicaceae). Gene 499:194-201. the ratio of rates…
Schaffner SF, Foo C, Gabriel S, Reich D, Daly MJ & Altshuler D 2005 Calibrating a coalescent simulation of human genome sequence variation. Genome Res 15:1576-1583. it is now possible to calibrate population genetic models with genome-wide…