Entries from 2020-01-01 to 1 year

polygenic adaptation

Stephan W & John S 2020 Polygenic adaptation in a population of finite size. Entropy 22:907. in recent years, due to the advance of genome-wide association studies (GWAS), polygenic selection was studied using quantitative genetics models …

polygenic adaptation

John S & Stephan W 2020 Important role of genetic drift in rapid polygenic adaptation. Ecol Evol 10:1278-1287. it is not clear if adaptation can occur rapidly via such subtle changes in the allele frequencies we follow this direction here …

polygenic adaptation

Mathieson I 2020 Human adaptation over the past 40,000 years. Curr Opin Genet Dev 62:97-104. despite strong evidence of the polygenicity of most human traits, evidence for polygenic selection is weak its importance in recent human evolutio…

genealogy

Wakeley J 2020 Developments in coalescent theory from single loci to chromosomes. Theor Popul Biol 133:56-64. it took some time to understand the temporal structure behind Ewens' formula working at first outside population genetics, Kingma…

multiple loci

Bürger R 2020 Multilocus population-genetic theory. Theor Popul Biol 133:40-48. commentary in linkage equilibrium (LE), allele frequencies at different loci do not change independently the direction and intensity of selection on a particul…

evolutionary rescue

Osmond MM, Otto SP & Martin G 2020 Genetic paths to evolutionary rescue and the distribution of fitness effects along them. Genetics 214:493-510. in multi-step rescue, intermediate genotypes that themselves go extinct provide a "springboar…

population expansion

Johri P, Charlesworth B & Jensen JD 2020 Toward an evolutionarily appropriate null model: jointly inferring demography and purifying selection. Genetics 215:173-192. previous studies have inferred ~two- to fourfold growth in the Zambian po…

separation of timescales

Martin G & Lambert A 2015 A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations. Theor Popul Biol 101:40-46. the main tool to obtain the distribution of allelic frequencies at at given time…

fixation time

Charlesworth B 2020 How long does it take to fix a favorable mutation, and why should we care? Am Nat 195:753-771. R. A. Fisher independently described a deterministic model of selection at an autosomal locus with discrete generations in a…

Wright-Fisher model

Waxman D & Overall ADJ 2020 Influence of dominance and drift on lethal mutations in human populations. Front Genet 11:267. a lethal disease-causing allele needs to be described by a modified Wright-Fisher model, which deviates from the sta…

soft sweep

Hartfield M & Bataillon T 2020 Selective sweeps under dominance and inbreeding. G3:1063-1075. a key property of soft sweeps is that the beneficial variant is present on multiple genetic backgrounds as it sweeps to fixation recessive allele…

polygenic adaptation

Sella G & Barton NH 2019 Thinking about the evolution of complex traits in the era of genome-wide association studies. Annu Rev Genom Hum Genet 20:461-493. the genetic architecture of a trait is informative about the population genetic pro…

polygenic adaptation

Hayward LK & Sella G 2019 Polygenic adaptation after a sudden change in environment. bioRχiv 792952. doi:10.1101/792952 hard sweeps were rare, at least over the past ~500,000 years of human evolution (13, 14) for many traits, estimates of …

polygenic adaptation

Thornton KR 2019 Polygenic adaptation to an environmental shift: temporal dynamics of variation under Gaussian stabilizing selection and additive effects on a single trait. Genetics 213:1513-1530. detectable "hitchhiking" patterns are only…