Entries from 2019-12-01 to 1 month

omnigenicity

Wray NR, Wijmenga C, Sullivan PF, Yang J & Visscher PM 2018 Common disease is more complex than implied by the core gene omnigenic model. Cell 173:1573-1580. Boyle et al. (2017b) [...] introduce the term "omnigenic," (omni = "all") in ackn…

omnigenicity

Boyle EA, Li YI & Pritchard JK 2017 The omnigenic model: response from the authors. J Psychiat Brain Sci 2:S8. one of our goals in writing this paper was to highlight an apparent paradox in human genetics most of the heritability for a typ…

missing heritability

Liu X, Li YI & Pritchard JK 2019 Trans effects on gene expression can drive ominigenic inheritance. Cell 177:1022-1034. we provide a formal model in which genetic contributions to complex traits are partitioned into direct effects from cor…