Entries from 2014-04-01 to 1 month
Evans DM, Gillespie NA & Martin NG 2002 Biometrical genetics. Biol Psychol 61:33-51. twin studies dominant genetic and common environmental components of variance cannot be estimated simultaneously these components are negatively confounde…
Moore JH, Asselbergs FW & Williams SM 2010 Bioinformatics challenges for genome-wide association studies. Bioinformatics 26:445-455. most SNPs discovered via GWAS have small effects on disease susceptibility and thus may not be suitable fo…
Brown AA, Buil A, Viñuela A, Lappalainen T, Zheng HF, Richards JB, Small KS, Spector TD, Dermitzakis ET, Durbin R 2014 Genetic interactions affecting human gene expression identified by variance association mapping. eLife 3:e01381. non-add…
Visscher PM, Brown MA, McCarthy MI & Yang J 2012 Five years of GWAS discovery. Am J Hum Genet 90:7-24. from McCLellan and King, Cell 20101: odds ratios of the magnitude generally detected by GWAS (value associated with them the common dise…
McClellan J & King M-C 2010 Genetic heterogeneity in human disease. Cell 141:210-217. rare mutations of severe effect are responsible for a substantial portion of complex human disease human disease is characterized by marked genetic heter…
Wright SI 2014 Mutationism 2.0: viewing evolution through mutation's lens. Evolution 68:1225-1227. review of: Nei M 2013 Mutation-driven evolution. Oxford UP. ISBN:9780199661732 investigators have also tried to establish the extent to whic…
Mackay TFC 2014 Epistasis and quantitative traits: using model organisms to study gene-gene interactions. Nat Rev Genet 15:22-33. the role of epistasis in the genetic architecture of quantitative traits is controversial this controversy ar…
Hemani G, Shakhbazov K, Westra H-J, Esko T, Henders AK, McRae AF, Yang J, Gibson G, Martin NG, Metspalu A, Franke L, Montgomery GW, Visscher PM & Powell JE 2014 Detection and replication of epistasis influencing transcription in humans. Na…
Hemani G, Knott S & Haley C 2013 An evolutionary perspective on epistasis and the missing heritability. PLoS Genet 9:e1003295. one reason that the problem of the "missing heritability" arises is because the additive genetic variation that …
Stringer S, Derks EM, Kahn RS, Hill WG & Wray NR 2013 Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits. PLoS ONE 8:e68913. heritability estimates from family (including twin studies) are bia…
Huang W, Massouras A, Inoue Y, Peiffer J, Ramia M, Tarone AM, Turlapati L, Zichner T, Zhu D, Lyman RF, Magwire MM, Blankenburg K, Carbone MA, Chang K, Ellis LL, Fernandez S, Han Y, Highnam G, Hjelmen CE, Jack JR, Javaid M, Jayaseelan J, Ka…
Lanfear R, Kokko H & Eyre-walker A 2014 Population size and the rate of evolution. TREE 29:33-41. the neutral substitution rate is not equal to the mutation rate in situations where there are overlapping generations and fluctuating populat…
Gazave E, Ma L, Chang D, Coventry A, Gao F, Muzny D, Boerwinkle E, Gibbs RA, Sing CF, Clark AG & Keinan A 2014 Neutral genomic regions refine models of recent rapid human population growth. PNAS 111:757-762. significance recent studies of …