Entries from 2013-12-01 to 1 month

population expansion

Gazave E, Chang D, Clark AG & Keinan A 2013 Population growth inflates the per-individual number of deleterious mutations and reduces their mean effect. Genetics 195:969-978. while population growth dramatically increases the number of del…

polygenic adaptation

Fu W & Akey JM 2013 Selection and adaptation in the human genome. Annu Rev Genom Hum Genet 14:467-489. the probability of a sweep from standing variation increases with larger effective population sizes this observation has important impli…

epistatic selection

Clark NL, Gasper J, Sekino M, Springer SA, Aquadro CF & Swanson WJ 2009 Coevolution of interacting fertilization proteins. PLoS Genet 5:e1000570. we studied female-male coevolution in the abalone by resequencing sperm lysin and its interac…

linkage disequilibrium

Sved JA 2011 The covariance of heterozygosity as a measure of linkage disequilibrium between blocks of linked and unlinked sites in Hapmap. Genet Res 93:285-290. calculations for a data set such as Hapmap are complicated by the large numbe…

epistatic selection

Rohlfs RV, Swanson WJ & Weir BS 2010 Detecting coevolution through allelic association between physically unlinked loci. Am J Hum Genet 86:674-685. we propose using both composite linkage disequilibrium (CLD) and a measure of association b…

epistatic selection

Koch E, Ristroph M & Kirkpatrick M 2013 Long range linkage disequilibrium across the human genome. PLoS ONE 8:e80754. the results show an excess of associations between pairs of distant sites (separated by > 0.25 cM) epistasis has been imp…