Entries from 2019-03-01 to 1 month

polygenic adaptation

Höllinger I, Pennings PS & Hermisson J 2019 Polygenic adaptation: from sweeps to subtle frequency shifts. PLoS Genet 15:e1008035. population genetics views adaptation as a sequence of selective sweeps at single loci underlying the trait qu…

polygenic adaptation

Stetter MG, Thornton K & Ross-Ibarra J 2018 Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima. PLoS Genet 14:e1007794. during the stationary phase before the shift and after reaching the new optim…

polygenic score

Barton N, Hermisson J & Nordborg M 2019 Why structure matters. eLife 8:e45380. the first GWAS for height found a small number of SNPs that jointly explained only a tiny fraction of the variation this was in contrast with the high heritabil…

polygenic score

Edge MD & Coop G 2019 Reconstructing the history of polygenic scores using coalescent trees. Genetics 211:235-262. standard population-genetic methods for inferring evolutionary history are lii-suited for polygenic traits when there are ma…

normality

Nicholson G, Smith AV, Jónsson F, Gústafsson Ó, Stefánsson K & Donnelly P 2002 Assessing population differentiation and isolation from single-nucleotide polymorphism data. J R Stat Soc B 64:695-715. in the Balding-Nichols (BN) model, allel…

normality

Kimura M 1954 Process leading to quasi-fixation of genes in natural populations due to random fluctuation of selection intensities. Genetics 39:280-295. the gene A is selectively neutral on the average Mδx = 0 Vδx = Vsx2(1 − x)2 ∂φ/∂t = (V…