epistasis

Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM & Weedon MN 2014 Another explanation for apparent epistasis. Nature 514:E3-E5.

• arising from G. Hemani et al.
• the apparent epistasis reported by Hemani et al. is more likely to be due to moderate levels of LD between each of the two SNPs and a single causal allele rather than genuine epistasis
• there remain few robust examples of epistasis in humans