epistasis

Moore JH 2009 From genotypes to genometypes: putting the genome back in genome-wide association studies. Eur J Hum Genet 17:1205-1206.

• there are not enough computers in the world to exhaustively enumerate all the three-way, four-way and five-way combinations of SNPs in a GWAS
• two or more genes with protein products that physically interact are more likely to exhibit a statistical interaction that can be detected in a human population