epistasis

Moore JH & Williams SM 2005 Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. BioEssays 27:637-646.

• one can argue that genetic and biological variation is sufficient for the statistical detection of epistasis
• does evidence of statistical epistasis necessarily imply biological epistasis?

• we are undergoing a more modern synthesis that merges multiple disciplines into what has been referred to as systems biology