deleterious mutation

Caballero A & Keightley PD 1994 A pleiotropic nonadditive model of variation in quantitative traits. Genetics 138:883-890.

• as mutant effects increase, there is a tendency toward recessivity
• we assumed an exponential function to define limits on the coefficient of dominance such that h' is a random value drawn from the uniform distribution such that h' < e^{− klal} and similarly, h < e^ks, where k is the parameter which gives the slope of the function