deleterious mutation

Theodorou K, Souan H & Couvet D 2009 Metapopulation persistence in fragmented landscapes: significant interactions between genetic and demographic processes. J Evol Biol 22:152-162.

• the dominance coefficient of mutations were obtained from an exponential function of the gene effects, h = e^{− ks} / 2 (Deng & Lynch, 1996)

• strong arguments are advanced in favour of the values we used (Lynch et al., 1999; Baer et al., 2007)
• recent studies argue that the rate of mutation per diploid genome could be significantly lower than U = 1 (Fry et al., 1999; Bataillon, 2000)
• a decrease in U has two effects
• first, it allows the metapopulation to persist for lower survival rates during dispersal
• second, reduces, although moderately, the value of the optimal dispersal rate