mutation accumulation
Higgins K & Lynch M 2001 Metapopulation extinction caused by mutation accumulation. PNAS 98:2928-2933.
- we let h(s) = 1 / (2 + 20s)
- mutations of large effect are almost recessive (as s → 1, h → 0.045), whereas those of small effect are almost additive (as s → 0, h → 1 / 2)
- consistent with observed data
- (Lynch et al. 1999; Greenberg & Crow 1960; Gillespie 1998)
