mutation accumulation

Lande R 1995 Mutation and conservation. Conserv Biol 9:782-791.

• because they arise at much higher spontaneous rates than do recessive lethal mutation, mildly detrimental mutations on the border of neutrality are the most damaging to population viability
• the inclusion of variance in selection coefficients in the model drastically decreases the mean time to extinction

• compensatory mutations at different loci are common, especially for quantitative characters under stabilizing selection (Fisher 1958:44-48)