hemizygous X
Wayne ML, Telonis-Scott M, Bono LM, Harshman L, Kopp A, Nuzhdin SV & McIntyre LM 2007 Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster. PNAS 104:18577-18582.
- hemizygosity of the X could cause fundamentally different modes of inheritance between the sexes
- with more additive variation in males and more nonadditive variation in females
- genetic variation for the transcriptome is primarily additive in males but nonadditive in females
- these differences are more pronounced on the X chromosome than the autosomes, but autosomal loci are also affected, possibly because of X-linked transcription factors
- hemizygosity of the X may underlie much of the faster male evolution of the transcriptome and potentially other phenotypes
- genes that are additive in males and nonadditive in females are overrepresented among genes responding to selection for increased mating speed
