deleterious mutation

Phadnis N & Fry JD 2005 Widespread correlations between dominance and homozygous effects of mutations: implications for theories of dominance. Genetics 171:385-392.

• empirical studies of mutations affecting viability in Drosophila (reviewed in Simmons and Crow 1977) have yielded estimates of dominance for lethal mutations of h = 0.02 and for mildly deleterious mutations of h = 0.35