Entries from 2009-01-01 to 1 year

flowering

Flowers JM, Hanzawa Y, Hall MC, Moore RC & Purugganan MD 2009 Population genomics of the Arabidopsis thaliana flowering time gene network. Mol Biol Evol, in press. doi:10.1093/molbev/msp161 a population genomic study of resequencing data f…

hybrid speciation

Taylor SJ, Arnold M & Martin NH 2009 The genetic architecture of reproductive isolation in Louisiana irises: hybrid fitness in nature. Evolution 63:2581-2594. a "genic view of speciation" specifically allows for large swaths of the genome …

population history

Strasburg JL & Rieseberg LH 2010 How robust are "Isolation with Migration" analyses to violations of the IM model? A simulation study. Mol Biol Evol, in press. doi:10.1093/molbev/msp233 the effects of a number of violations of the "Isolati…

missing heritability

Dermitzakis ET & Clark AG 2009 Life after GWA studies. Science 326:239-240. genome-wide association findings should be integrated into a wider scope of information, including biological processes and environments the heritability of statur…

missing heritability

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, David Valle D, Whittemore AS, Boehnke M, Clar…

data sharing

Chen X, Cho K, Singer BH & Zhang H 2009 Retraction. PNAS 106:17241.Schekman R 2009 PNAS takes action regarding breach of NIH embargo policy on a PNAS paper. PNAS 106:16893.Guttmacher AE, Nabel EG & Collins FS 2009 Why data-sharing policies…

developmental constraint

Arthur W 2004 The effect of development on the direction of evolution: toward a twenty-first century consensus. Evol Dev 6:282-288. Gould & Lewontin (1979) ... was a deliberate attempt to provoke a response from the neo-Darwinian school on…

human genetics

Hayden EC 2009 Genomics shifts focus to rare diseases. Nature 461:458-459. studying the rare stuff because it bears on the common stuff the issue is how we're going to understand the architecture of common disorders three or four years ago…

geographic structure

Holsinger KE & Weir BS 2009 Genetics in geographically structured populations: defining, estimating and interpreting FST. Nat Rev Genet 10:639-650. until Cockerham introduced his indicator formalism10,22, few if any population geneticists …

cis-trans compensation

Carter AJR & Wagner GP 2002 Evolution of functionally conserved enhancers can be accelerated in large populations: a population-genetic model. Proc R Soc Lond B 269:953-960. the rate of evolution by pairs of compensatory mutations increase…

human evolution

White TD, Asfaw B, Beyene Y, Haile-Selassie Y, Lovejoy CO, Suwa G & WoldeGabriel G 2009 Ardipithecus ramidus and the paleobiology of early hominids. Science 326:75-86.

speciation

Presgraves DC & Yi SV 2009 Doubts about complex speciation between humans and chimpanzees. TREE 24:533-540. there is no discrepancy that requires a lower divergence time (i.e. gene flow) for the X chromosome between humans and chimpanzees

evolvability

Cuevas JM, Moya A & Sanjuán 2009 A genetic background with low mutational robustness is associated with increased adaptability to a novel host in an RNA virus. J Evol Biol 22:2041-2048. robustness can promote evolvability only in systems w…

directional epistasis

Sanjuán R & Nebot MR 2008 A network model for the correlation between epistasis and genomic complexity. PLoS ONE 3:e2663. in simpler genomes epistasis is antagonistic on average a transition towards synergistic epistasis occurs in more com…

deleterious mutation

Keightley PD & Eyre-Walker A 1999 Terumi Mukai and the riddle of deleterious mutation rates. Genetics 153:515-523. one approach to estimating the mutation rate to deleterious, but nonlethal, mutations is to use information on the rate at w…

deleterious mutation

Keightley PD, Caballero A & García-Dorado A 1998 Population genetics: surviving under mutation pressure. Curr Biol 8:R235-R237. it is extremely difficult to obtain information on the impact of mildly deleterious mutations currently, much o…

deleterious mutation

Eyre-Walker A & Keightley PD 2007 The distribution of fitness effects of new mutations. Nat Rev Genet 8:610-618. there is also some evidence that the DFE of homozygous non-lethal mutations is multi-modal

deleterious mutation

Bataillon T 2000 Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations? Heredity 84:497-501.

deleterious mutation

Phadnis N & Fry JD 2005 Widespread correlations between dominance and homozygous effects of mutations: implications for theories of dominance. Genetics 171:385-392. empirical studies of mutations affecting viability in Drosophila (reviewed…

deleterious mutation

Fry JD 2001 Rapid mutational declines of viability in Drosophila. Genet Res 77:53-60. Mukai and Ohnishi may have confounded viability declines caused by mutation with declines resulting from environmental changes or other extraneous factor…

deleterious mutation

Fry JD, Keightley PD, Heinsohn SL & Nuzhdin SV 1999 New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster. PNAS 96:574-579. the most detailed information comes from the work of Mukai and Ohnishi w…

deleterious mutation

García-Dorado A, López-Fanjul C & Caballero A 1999 Properties of spontaneous mutations affecting quantitative traits. Genet Res 74:341-350. although the rate (λ) and effect (s) of very slight deleterious mutation remain unknown, most mutat…

deleterious mutation

García-Dorado A & Caballero A 2000 On the average coefficient of dominance of deleterious spontaneous mutations. Genetics 155:1991-2001. the results of these experiments, although inconsistent, have been interpreted as indicating slight re…

deleterious mutation

Rodríguez-Ramilo ST, Pérez-Figueroa A, Fernández B, Fernández J & Caballero A 2004 Mutation-selection balance accounting for genetic variation for viability in Drosophila melanogaster as deduced from an inbreeding and artificial selection …

deleterious mutation

García-Dorado A, López-Fanjul C & Caballero A 2004 Rates and effects of deleterious mutations and their evolutionary consequences. Pages 20-32 in Moya A & Font E, eds. Evolution: from molecules to ecosystems. Oxford UP. ISBN:9780198515432

deleterious mutation

Caballero A, Cusi E, García C & García-Dorado A 2002 Accumulation of deleterious mutations: additional Drosophila melanogaster estimates and a simulation of the effects of selection. Evolution 56:1150-1159. the simulation results indicated…

deleterious mutation

Caballero A & Keightley PD 1994 A pleiotropic nonadditive model of variation in quantitative traits. Genetics 138:883-890. as mutant effects increase, there is a tendency toward recessivity we assumed an exponential function to define limi…

deleterious mutation

Theodorou K, Souan H & Couvet D 2009 Metapopulation persistence in fragmented landscapes: significant interactions between genetic and demographic processes. J Evol Biol 22:152-162. the dominance coefficient of mutations were obtained from…

deleterious mutation & geographic structure

Theodorou K & Couvet D 2006 Genetic load in subdivided populations: interactions between the migration rate, the size and the number of subpopulations. Heredity 96:69-78. in order to investigate the relative importance of the parameters th…

deleterious mutation & demography

Thévenon S & Couvet D 2002 The impact of inbreeding depression on population survival depending on demographic parameters. Anim Conserv 5:53-60. a mix of 95% of mildly deleterious alleles and 5% of strongly detrimental alleles was consider…