human genetics

Hayden EC 2009 Genomics shifts focus to rare diseases. Nature 461:458-459.

• studying the rare stuff because it bears on the common stuff
• the issue is how we're going to understand the architecture of common disorders
• three or four years ago I thought it was going to be because of GWAS studies
• I now think that we're going to get there by understanding a whole lot of these Mendelian diseases