epistasis

Gao H, Granka JM & Feldman MW 2010 On the classification of epistatic interactions. Genetics 184:827-837.

• aside from the distinction between the statistical and the physiological definitions of epistasis, inconsistencies exist when studying solely physiological epistasis

• minimum epistasis is more prevalent than both additive and multiplicative epistasis and that the overall distribution of ε is not significantly different from zero
• as Jasnos and Korona 2007 suggest

• the additive and multiplicative models are widely used to represent independence, while the minimum model is used by investigators searching for synthetic lethal double mutants
• the Log model is practically equivalent to the multiplicative model for deleterious mutations