transcriptional regulation

Kasowski M, Grubert F, Heffelfinger C, Hariharan M, Asabere A, Waszak SM, Habegger L, Rozowsky J, Shi M, Urban AE, Hong M-Y, Karczewski KJ, Huber W, Weissman SM, Gerstein MB, Korbel JO & Snyder M 2010 Variation in transcription factor binding among humans. Science 328:232-235.

• binding differences were frequently associated with single-nucleotide polymorphisms and genomic structural variants
• these differences were often correlated with differences in gene expression, suggesting functional consequences of binding variation
• comparing PolII binding between humans and chimpanzee suggests extensive divergence in TF binding
• many differences in individuals and species occur at the level of TF binding
• they provide insight into the genetic events responsible for these differences