complex adaptation

Pérez Heredia J, Trubenová B, Sudholt D & Paixão T 2017 Selection limits to adaptive walks on correlated landscapes. Genetics 205:803-825.

• pleiotropy is not the only source for this cost of complexity
• even when mutations act on single "traits," there is a penalty for having longer sequences
• mutational pressure and the structure of the fitness landscape play an important role on this cost of complexity
• this is a direct consequence of the fact that we deal with discrete sequence spaces and not with a continuous trait space, as in traditional formulations of Fisher’s geometric model