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Pavlidis P, Jensen JD, Stephan W & Stamatakis A 2012 A critical assessment of storytelling: gene ontology categories and the importance of validating genomic scans. Mol Evol Biol 29:3237-3248.

• a disadvantage of using empirical distributions for detecting regions that have experienced positive selection is that the proportion of the genome that has experienced positive selection is unknown
• therefore the number of detected genetic regions is likely to be over- or underestimated
• it is unknown whether true-positives will preferentially populate the tail of the distribution, particularly in nonequilibrium populations

• the overlap between lists of candidate genes for positive selection from various studies in the human populations is limited
• candidate gene sets are mostly disjoint among studies