epistasis
Breen MS, Kemena C, Vlasov PK, Notredame C & Kondrashov FA 2012 Epistasis as the primary factor in molecular evolution. Nature 490:535-538.
- epistasis—nonlinear genetic interactions between polymorphic loci
- an epistatic perspective of molecular evolution leads to the formulation of several fundamental questions, in addition to the largely unanswered questions posed by John Maynard Smith in 1970
- out of the entire network of pairwise epistatic interactions between sites across the genome, are there many non-overlapping epistatic subnetworks or are most sites interconnected within the entire network of epistatic interactions?
- what is the ratio of intergenic to intragenic epistatic interactions?
- pervasive epistasis in long-term protein evolution raises the possibility that similar epistatic interactions may be prevalent in short-term evolution
- situations when a polymorphism is benign or beneficial to one individual but deleterious to another individual within the same population may be more common than is thought at present
