transcriptional regulation

Odom DT, Dowell RD, Jaconbsen ES, Gordon W, Danford TW, MacIsaac KDRolfe PA, Conboy CM, Gifford DK & Fraenkel E 2007 Tissue-specific transcriptional regulation has diverged between human and mouse. Nat Genet 39:730-732.

• the binding sites for highly conserved transcription factors vary extensively between human and mouse
• despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific
• when the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align

• the location of binding events varies widely between species in ways that cannot be predicted from human-mouse sequence alignments alone
• the binding site for HNF6 at IGFBP1 shifted over 4 kb from the promoter region in humans to the first intron in mice