Wright-Fisher model

Waxman D 2009 Fixation at a locus with multiple alleles: structure and solution of the Wright Fisher model. J Theor Biol 257:245-251.

• the distribution of allele frequencies in adults is directly determined from the distribution of adult genotypes, which is approximately multinomial
• when thinning occurs in diploid individuals, it does not automatically follow that the distribution of alleles in adults will also be multinomial
• this point is made by Nagylaki (1992, p. 252)
• a multinomial distribution of allele frequencies is only guaranteed to follow from multiplicative viabilities
• i.e., in the absence of dominance at the locus in question