PPR
Castandet B & Araya A 2012 The nucleocytoplasmic conflict, a driving force for the emergence of plant organellar RNA editing. IUBMB Life 64:120-125.
- mitochondrial proteins translated from edited messenger RNA (mRNA) are more similar to the homologous counterparts from organisms that do not undergo RNA editing
- this process is a correction mechanism occurring before mRNA translation
- an editing defect should lead to a protein with reduced activity, thus affecting mitochondrial function
- additional evidence that the lack of editing can lead to a male sterile phenotype comes from experimentally engineered plants
- expression of the unedited version of the wheat atp9 (u-atp9), but not the edited one, results in male sterility
- suppression of u-atp9 expression restores fertility
- the Rf genes and editing factors described to date belong to both P and PLS subfamilies of PPR genes
- recent studies do not support a clear distinction in the functional roles between the two subfamilies
- despite differences in structure, their modes of action are quite similar in terms of RNA binding activity and posttranscriptional functions
