fisherian geometry

Peck JR, Barreau G & Heath SC 1997 Imperfect genes, Fisherian mutation and the evolution of sex. Genetics 145:1171-1199.

• mutant effects are biased
• there is a correlation between the state of an allele before mutation, and its postmutation state

• a mutation is assumed to change the value associated with an allele by an amount m
• the mutated value of the allele is given by x = m + x*
• the distribution of m used in the simulation studies is a "reflected gamma"