soft sweep

Pokalyuk C 2012 The effect of recurrent mutation on the linkage disequilibrium under a selective sweep. J Math Biol 64:291-317.

  • hard sweeps dominate for θs < 0.01
  • both hard sweeps and soft sweeps occur in the range 0.01 < θs < 1
  • for θs > 1, almost all adaptive substitutions will result in soft sweeps
  • in Drosophila melanogaster there should exist many soft sweeps due to tremendous short-term effective population sizes relevant for adaptation
  • ongoing research argues for the importance of soft sweeps and polygenic adaptation
  • tests based on haplotype structure have higher power to detect soft sweeps