epistasis
Jarvis JP & Cheverud JM 2011 Mapping the epistatic network underlying murine reproductive fatpad variation. Genetics 187:597-610.
- contrary to suggestions based on human genome-wide association study findings, we found substantial numbers of pairwise epistatic interactions involving many more loci than show single-locus effects that account for an important portion of trait variation
- this is likely due to the genetic structure of our experimental population where allele frequencies are intermediate
- this is critical since epistasis is known to produce predominantly additive and dominance variance when relatively rare alleles are involved
