pleiotropy
Streisfeld MA & Rausher MD 2010 Population genetics, pleiotropy, and the preferential fixation of mutations during adaptive evolution. Evolution 65:629-642.
- fixation bias can be strong ..., likely due to differences in the magnitude of deleterious pleiotropy associated with alternative mutation categories
- some mutations for a particular novel trait may arise more frequently than others
- mutation bias
- mutations may have different probabilities of being fixed once they arise
- fixation bias
- the usual explanation for biased fixation is that different mutation types experience different magnitudes of deleterious pleiotropy
- biased fixation contributes substantially to the observation that cis-regulatory mutations are more common in morphological divergence between species
- it would be desirable to use an approach that explicitly differentiates between biases associated with rates of mutation and probabilities of fixation
