markovian
Kondrashov AS, Povolotskaya IS, Ivankov DN & Kondrashov FA 2010 Rate of sequence divergence under constant selection. Biol Direct 5:5.
- we assume that Neμi, j ≪ 1 for all i, j, so that most of the time one of the alleles is fixed in the population [3]
- the dynamics of the model consists of allele replacements occurring at a site at random moments
- Reviewer 1
- Nicolas Galtier
- this manuscripts implements a very good idea
- namely injecting population genetic parameters, typically used to model microevolution, in substitution matrices, typically used to model long-term sequence evoution
- the two must be connected in principle, yet classical Markov models used in phylogenetics are made of arbitrary parameters
- they perhaps do not apply so frequently to real data
- given the assumptions of constant in time population size and selection coefficients
- at any rate, this piece might stimulate other studies trying to understand long-term sequence evolution in the light of population genetics
