deleterious mutation

Ossowski S, Schneeberger K, Lucas-Lledó JI, Warthmann N, Clark RM, Shaw RG, Weigel D & Lynch M 2010 The rate and molecular spectrum of spontaneous mutations in Arabidopsis thaliana. Science 327:92-94.

• if we assume that only nonsynonymous mutations and indels affecting coding regions are likely to affect fitness, the diploid genomic rate of mutations affecting fitness would be 0.2 ± 0.1 per generation
• which is not significantly different from previous estimates based on the evaluation of fitness components in MA lines of A. thaliana
• alternatively, the proportion of deleterious mutations among mutations in coding regions can be estimated from sequence comparisons between A. thaliana and A. lyrata
• using that information, the estimated genomic deleterious mutation rate is 0.14 ± 0.04 per generation