gene duplication

Kehrer-Sawatzki H & Cooper DN 2008 Divergence between the human and chimpanzee genomes and its impact on protein and transcriptome evolution. Encyclopedia Life Sci a0006115.

• many members of gene families with multiple paralogues are highly rearranged by comparison with the source locus
• these rearrangements are mostly associated with domain or exon accretion
• a process which allows the avoidance of potentially deleterious gene dosage effects and which drives the evolution of new genes