cis versus trans effects

Sung H-M, Wang T-Y, Wang D, Huang Y-S, Wu J-P, Tsai H-K, Tzeng J, Huang C-J, Lee Y-C, Yang P, Hsu J, Chang T, Cho C-Y, Weng L-C, Lee T-C, Chang T-H, Li W-H & Shih M-C 2009 Roles of trans and cis variation in yeast intraspecies evolution of gene expression. Mol Biol Evol 26:2533-2538.

• we used Saccharomyces cerevisiae as a model organism to estimate the relative contributions of cis and trans variations to the expression divergence between a laboratory (BY) and a wild (RM) strain of yeast
• we examined the expression patterns of these genes in a BY–RM coculture system and in a BY–RM diploid hybrid
• we found that trans variation is far more important than cis variation for expression divergence between the two strains