missing heritability

Slatkin M 2009 Epigenetic inheritance and the missing heritability problem. Genetics 182:845-850.

• the solution to the problem of missing heritability is not necessarily the same as the solution to the problem of missing causality
• as has been pointed out by Hemminki et al. (2008)

• unless epigenetic marks persist for many generations, they are unlikely to contribute much to missing heritability because identity by descent does not imply identity in state
• they may well contribute to missing causality despite their having a weak effect on heritability