sequence diversity

Sella G, Petrov DA, Przeworski M & Andolfatto P 2009 Pervasive natural selection in the Drosophila genome? PLoS Genet 5:e10000495.

• Neutral Theory

• (i) the vast majority of newly arising mutations are neutral or strongly deleterious
• (ii) most fixed differences between species are neutral, with a negligible contribution of adaptive mutations
• (iii) the effects of both positive and negative selection at linked loci on the dynamics of neutral alleles can be ignored