Hancock AM, Alkorta-Aranburu G, Witonsky DB & Di Rienzo A 2010 Adaptations to new environments in humans: the role of subtle allele frequency shifts. Phil Trans R Soc Lond B 365:2459-2468. we contrast the results of approaches based on hap…

Pritchard JK & Di Rienzo A 2010 Adaptation — not by sweeps alone. Nat Rev Genet 11:665-667. within the population genetics community, adaptation is typically viewed as involving selective sweeps that drive beneficial alleles from low to hi…

Lynch M & Abegg A 2010 The rate of establishment of complex adaptations. Mol Biol Evol 27:1404-1414. a central problem in evolutionary theory concerns the mechanisms by which adaptations requiring multiple mutations emerge in natural popul…

Lynch M 2010 Scaling expectations for the time to establishment of complex adaptations. PNAS 107:16577-16582. one strategy has been to ignore all deleterious mutations and to assume that selection is strong enough and mutation weak enough …

Weissman DB, Feldman MW & Fisher DS 2010 The rate of fitness-valley crossing in sexual populations. Genetics, in press. doi:10.1534/genetics.110.123240 ISSUE HIGHLIGHTS how do populations acquire complex adaptations that require multiple m…

Weissman DB, Desai MM, Fisher DS & Feldman MW 2009 The rate at which asexual populations cross fitness valleys. Theor Popul Biol 75:286-300. once a beneficial mutation is established (upon reaching a size of order 1 / s), its frequency wil…

Neher RA, Shraiman BI & Fisher DS 2010 Rate of adaptation in large sexual populations. Genetics 184:467-481. adaptation often involves the acquisition of a large number of genomic changes that arise as mutations in single individuals in as…

Iwasa Y, Minchor F & Nowak MA 2004 Stochastic tunnels in evolutionary dynamics. Genetics 166:1571-1579. cells reproduce asynchronously we use a Moran process instead of the standard Wright-Fisher model each elementary step of the stochasti…

Wang Y, Diehl A, Wu F, Vrebalov J, Giovannoni J, Siepel A & Tanksley SD 2008 Sequencing and comparative analysis of a conserved syntenic segment in the Solanaceae. Genetics 180:391-408. despite their great phenotypic diversity, all Solanac…

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Masel J & Trotter MV 2010 Robustness and evolvability. Trends Genet 26:406-414. robustness to mutation allows genetic variation to accumulate in a cryptic state hybridization between two dissimilar lineages can be thought of as a major one…

Takahashi KH, Rako L, Takano-Shimizu T, Hoffmann AA & Lee SF 2010 Effects of small Hsp genes on developmental stability and microenvironmental canalization. BMC Evol Biol 10:284.

Rosas U, Barton NH, Copsey L, Barbier de Reuille & Coen E 2010 Cryptic variation between species and the basis of hybrid performance. PLoS Biol 8:e1000429. the species lie on a plateau in gene expression-morphology space, so that the varia…

Fierst JL & Hansen TF 2010 Genetic architecture and postzygotic reproductive isolation: evolution of Bateson-Dobzhansky-Muller incompatibilities in a polygenic system. Evolution 64:675-693. reproductive isolation under stabilizing selectio…

Heidel AJ, Ramos-Onsins AJ, Wang W-K, Chiang T-Y & Mitchell-Olds T 2010 Population history in Arabidopsis halleri using multilocus analysis. Mol Ecol 19:3364-3379. given the difficulties in accurately obtaining both alleles from each indiv…

Alexander DH, Novembre J & Lange K 2009 Fast model-based estimation of ancestry in unrelated individuals. Genome Res 19:1655-1664. structure takes a Bayesian approach and relies on a Markov chain Monte Carlo (MCMC) algorithm to sample the …

Flint J & Mackay TFC 2009 Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res 19:723-733. to map QTLs in rodents, about 100 markers and a few hundred animals were sufficient to provide robust statistical evid…

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Wade MJ 2007 The co-evolutionary genetics of ecological communities. Nat Rev Genet 8:185-195. I show how the co-inheritance of trans-specific gene combinations can be estimated using a parameter that was devised to measure epistasis betwee…

Nuismer SL, Gomulkiewicz R & Ridenhour BJ 2010 When is correlation coevolution? Am Nat 175:525-537. coevolution is neither a necessary nor a sufficient condition for the evolution of spatially correlated traits between two species coevolut…

Gandon S & Nuismer SL 2009 Interactions between genetic drift, gene flow, and selection mosaics drive parasite local adaptation. Am Nat 173:212-224. after selection, gene flow between habitats occurred with the probability of moving betwee…

Gavrilets S & Michalakis Y 2008 Effects of environmental heterogeneity on victim–exploiter coevolution. Evolution 62:3100-3116. such heterogeneity in fitness may help to maintain polymorphism and population differentiation as has been obse…

Gandon S 2002 Local adaptation and the geometry of host–parasite coevolution. Ecol Lett 5:246-256. genetic drift may decouple the dynamics of the different populations and counteract the effect of migration genetic drift is classically vie…

Cifuentesa M, Eberb F, Lucasb M-O, Lodeb M, Chèvreb A-M & Jenczewskia E 2010 Repeated polyploidy drove different levels of crossover suppression between homoeologous chromosomes in Brassica napus allohaploids. Plant Cell 22:2265-2276. poly…

Koh J, Soltis PS & Soltis DE 2010 Homeolog loss and expression changes in natural populations of the recently and repeatedly formed allotetraploid Tragopogon mirus (Asteraceae). BMC Genomics 11:97. many polyploid species have formed repeat…

Meimberg H, Rice KJ, Milan NF, Njoku CC & McKay JK 2009 Multiple origins promote the ecological amplitude of allopolyploid Aegilops (Poaceae). Am J Bot 96:1262-1273. polyploid species can exhibit higher ecological tolerance than their prog…

Wang J, Tian L, Lee HS, Wei NE, Jiang H, Watson B, Madlung A, Osborn TC, Doerge RW, Comai L & Chen ZJ 2006 Genomewide nonadditive gene regulation in Arabidopsis allotetraploids. Genetics 172:507-517.

Meer MV, Kondrashov AS, Artzy-Randrup Y & Kondrashov FA 2010 Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness. Nature 464:279-282. fitness landscapes traversed by switches between different AU and GC Watson–Cr…

Nei M, Suzuki Y & Nozawa M 2010 The neutral theory of molecular evolution in the genomic era. Annu Rev Genom Hum Genet 11:265-289. at present, genome-wide analyses of natural selection consist of collections of single-locus analyses phenot…

Nei M 2007 The new mutation theory of phenotypic evolution. PNAS 104:12235-12242. I want to emphasize that any mutation would never be strictly neutral because its function depends on other genes and environmental conditions in this sense,…